Neutropenia (low white blood cells)

 

Similar to a drop in hemoglobin related to ribavirin, interferon caused a drop in white blood cells (WBC), manufactured in the bone marrow. Hite blood cells are used to fight infections in the body. If the WBC drops below an acceptable value, G-CSF (filgrastin) may be used. This stimulated the bone marrow to produce WBC, raising their value above acceptable limits. Similar to ribavirin, it seems beneficial to maintain the appropriate dose of interferon rather than dose reduce. If the WBC is below a critical level, therapy may be reduced or discontinued. G-CSF is associated with certain adverse reactions including skin rash, bone pain, muscle aches, and an exacerbation of psoriasis.